This article is to discuss the clinical picture of T.B ( manifestations | symptoms and signs ) . TB is usually classified as pulmonary or extrapulmonary. In absence of HIV infection, it involves the lungs only in > 80% of cases. In presence of HIV, up to 2/3 of patientswith TB have either extrapulmonary disease alone or both pulmonary and extrapulmonary disease.I- Clinical picture of Primary complex (it is often seen in children) In most cases the primary infection produces no symptoms or signs. Fever, dry cough may occur for 1-2 weeks so, the condition usually passed unnoticed unless the following investigations are done. : - Chest x-ray , Sputum examination - Tuberculin test shows conversion from -ve to +veSo clinical disease results from the development of hypersensitivity or progression of the primary complex. (A) Hypersensitivity: to tubercle bacilli may occur leading to: a- Erythema nodosum * Bluish red nodule * Raised * Tender * Cutaneous on the skin of tibia * Tuberculin test is strongly + ve b- Pleural effusion===> exudative reaction (Hypersensitivity) c- Phylectinular conjunctivitis. (B) Progression of primary pulmonary tuberculosis : Read more at : Manifestations of Pulmonary Tuberculosis